摘要 |
<p>Disclosed are 16-Nor-pregnahexaenes of the general formula (I) wherein A, R1, W, Q, Y, Z and R3 have the meanings defined in claim 1 hereof. These compounds are novel with the exception of the 21-acetate and 3,21-diacetate of 19-nor-pregna-1,3,5(10),6,8,14-hexaene-3,17.alpha.,21-triol-20-one, while pharmaceuticla compositions containing the latter two compounds are also novel. The preparation of the novel compounds by three methods is described, in particular dehydrogenation in position 14 of appropriate 19-nor-pregna-1,3,5(10),6,8-pentae-nes by means of DDQ. Reprensentative compounds of the inventions have been shown to exhibit antimitotic activity and, in particular, are useful in treating psoriasis.</p> |