METHOD FOR PREPARING HYDROCHLORIDE OF N-ALKYL DERIVATIVES OF 1-PHENYL-2-AMINO-1,3-PROPANEDIOL

摘要

The invention relates to novel 1-phenyl-2-amino-1,3-propanediol-N-alkyl derivatives having the general formula I (I) wherein R1 is hydrogen, alkyl having from 1 to 8 carbon atoms or phenoxymethyl, and R2 is hydrogen, alkyl having from 1 to 8 carbon atoms or 2,2-diphenylethyl, with the proviso that if R1 is phenoxymethyl then R2 may stand only for methyl, and if R2 is 2,2-diphenylethyl then R1 may stand only for hydrogen, and its isomers and pharmaceutically acceptable salts. Furthermore, the invention relates to a process for preparing these compounds. The novel 1-phenyl-2-amino-1,3-propanediol-N-alkyl derivatives having the general formula I possess significant anti-anginose activity and show several other biological activities.