发明名称 |
Antibacterial amide compounds and pharmaceutical composition containing the same |
摘要 |
Novel organic amide compounds which are N-[6-(sulfonylaminophenyl)-1,2-dihydro-2-oxonicotinoyl]penicillin compounds having broad spectrum antibacterial utility are provided by (a) reacting the free amino acid of the appropriate penicillin or the acid salt or silylated derivative or complex thereof with a reactive derivative of the corresponding N-6-(sulfonylaminophenyl)-1,2-dihydro-2-oxonicotinic acid or (b) reacting the free amino acid 6-aminopenicillanic acid or a related compound or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding D-N-[6-(sulfonylaminophenyl)-1,2-dihydro-2-oxonicotinoyl]-2-substituted glycine. Pharmaceutical compositions containing said compounds and methods for treating infections using said compositions are also disclosed.
|
申请公布号 |
US4315014(A) |
申请公布日期 |
1982.02.09 |
申请号 |
US19800190109 |
申请日期 |
1980.09.24 |
申请人 |
WARNER-LAMBERT COMPANY |
发明人 |
MICH, THOMAS F.;DOUB, LEONARD |
分类号 |
C07D213/64;C07D499/00;C07D499/64;(IPC1-7):A61K31/44;C07D499/70;C07D211/76 |
主分类号 |
C07D213/64 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|