| 摘要 |
<p>X-4658B Novel tetrahydro-2H-benzo¢c!pyrroles, useful as dopamine agonists, particularly as inhibitors of prolactin secretion and in treatment of Parkinson's syndrome, are described herein. These compounds are prepared by reacting a dl-5-amino-4,5,6,7-tetahydro-2H-benzo¢c!pyrrole with an aldehyde and then a reducing agent or with an alkyl halide, then an acyl halide followed by a reducing agent; and optionally with an alkyl halide and base. Also described are novel intermediates having the general formula IA wherein R1 is H or ; Am is NH2 or ; R3 is methyl, ethyl or n-propyl; except that R1 is not when Am is NH2; and the acid addition salts thereof when Am is NH2.</p> |
