发明名称 N-Acyl derivatives of glucosamine having antitumor chemotherapeutic acitivity
摘要 N-acyl derivatives of D-hexosamine made by linking an oligopeptide having a m-di(2-chloroethyl)amino-L-phenylalanyl residue to the amino groups of two hexosamine molecules by a peptide bond, are endowed with strong antitumor action against transplanted neoplasms in animals. Compounds according to the present invention are: <IMAGE> and its salts with organic or inorganic acids physiologically tolerated. The antineoplastic activity of the compounds of the present invention is not affected in the gastrointestinal tract and hence they can be effectively administered orally.
申请公布号 US4314999(A) 申请公布日期 1982.02.09
申请号 US19800173621 申请日期 1980.07.30
申请人 PROTER S.P.A. 发明人 DE BARBIERI, AUGUSTO
分类号 C07H13/04;C07H15/04;(IPC1-7):A61K37/02;C07C103/52 主分类号 C07H13/04
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