Certain pyrrole analogs of prostacyclin derivatives

摘要

Prostane derivatives of the formula <IMAGE> wherein R1 is (a) hydrogen, (b) C1-10 alkyl, (c) C1-10 alkyl substituted by halogen; C1-4 alkoxy; C6-10 aryl; C6-10 aryl substituted by 1-3 halogen atoms, a phenyl group, 1-3 C1-4 alkyl groups or a chloromethyl, fluoromethyl, trifluoromethyl, carboxy, hydroxy or C1-4 alkoxy group; di-C1-4-alkylamino; or tri-C1-4alkylammonium; (d) C4-10 cycloalkyl, (e) C4-10 cycloalkyl substituted by C1-4 alkyl, (f) C6-10 aryl, (g) C6-10 aryl substituted by 1-3 halogen atoms, a phenyl group, 1-3 C1-4 alkyl groups or a chloromethyl, fluoromethyl, trifluoromethyl, carboxy, hydroxy or C1-4 alkoxy group, or (h) an aromatic heterocycle of 5 or 6 ring atoms one of which is O, N or S; W is hydroxymethylene or RO-methylene; or <IMAGE> wherein OH or OR is in the alpha -position and R is an in vivo hydrolyzable and physiologically acceptable ether or acyl group which is conventional for modifying OH groups in prostaglandins; R3, R4, R5 and R6 are each independently hydrogen or alkyl of 1-5 carbon atoms, R2 is OH or OR, R being as defined above, or, when R1 is H, a physiologically compatible salt thereof with a base.