| 摘要 |
5ss-hydroxy-//c<s6>s-steroid derivatives having the general formula (FORMULA) wherein R<s1>s represents a hydrogen atom, an acyl, lower alkyl or tetrahydropyranyl residue and R<s2>s, R<s3>s each a hydrogen atom or in common a methylene residue and X is an oxygen atom or a group having the formula (FORMULA) (wherein R<s4>s is a hydrogen atom or an acyl residue) and (FORMULA) (wherein R<s5>s is a hydrogen atom or a lower alkyl residue). The invention also relates to a method for preparing such compounds by reacting corresponding 7//c-chlorene - 5ss, 6 ss-epoxy steroids in an inert solvent with zinc metal in a lower aliphatic carboxylic acid or in a diluted inorganic acid and, at temperatures between room temperature and 100`C, preferably between 40 and 70`C. The thus obtained compounds are intermediary products allowing the preparation of 3-keto-//c<s4>s-6ss, 7ss-methylene steroids; the latter being useful pharmacological substances, e.g. aldosterone antagonists. |
