SALTS OF 2-HYDROXYMALONATO DIAMMINE PLATINUM (II) COMPOUNDS, PROCESS FOR PREPARING SAID COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID COMPOUNDS

摘要

Disclosed are water-soluble salts of the known antitumor agents 2-hydroxymalonato diammine platinum (II), 2-hydroxymalonato (1,2-diaminocyclohexane)platinum (II) and 2-hydroxymalonato (1,1-diaminomethylcyclohexane)-platinum (II). The novel sodium and ammonium salts of the present invention possess high water-solubility, thus allowing intravenous dosage forms to be prepared for treatment of mammalian tumors.