N-(thio)acyl carbamoyl-glycylamino-cephalosporin ic acids - as antibiotics esp. active against pseudomonas and gram neg. organisms producing cephalosporinase

摘要

Cpds. (I) (where Y is O or S; R1 is an organic radical contg. up to 20C; R2 is 1-3C alkyl or PhCH2 or R2+R3 together with N and C atoms forms a 5-, 6- or 7-membered ring; R3 is Ph opt. substd. by halogen, OH, NO2, 1-3C alkoxy, or amino, thienyl, 3-7C cycloalkyl or 1-4C alkyl and R4 is acetoxy or a nucleophilic radical linked via a C, N or S atom) are prepd. by acylating a 7-amino- or 7-glyclylamino-cephalosporinic acid or a delta 3 silyl-, ester or S-oxide deriv. there of or replacing a 3-acetoxy group by R4 and then removing blocking groups or S-oxides or isomerising the delta 3 isomers).