| 摘要 |
3,6,7,8-substituted-s-triazolo pyridazine compounds of the formula <CHEM> wherein R3 represents hydrogen or loweralkyl, R6 represents amino, loweralkylamino, diloweralkylamino, heterocyclic amino or lower alkyl substituted heterocyclic amino, wherein the heterocyclic moiety forms a 5, 6 or 7 membered ring, having one or two ring nitrogen atoms and zero or one ring sulfur or oxygen atom; T7 represents loweralkyl; R8 represents hydrogen or loweralkyl; or R7 and R8 taken together represent polymethylene of 3 or 4 methylene units or polymethylene substituted by lower alkyl, or methano or ethano bridges; and their pharmacologically acceptable salts are made by reacting a carboxylic acid with a substituted 3-hydrazino-6-halo-pyridazine and then reacting the resulting 6-halotriazolopyridazine with a corresponding base. The compounds have pharmacological activity as bronchodilators. |
