发明名称 |
5-(Pyridinyl)-6-(lower-alkyl)-2(1H)-pyridinones, 1,2-dihydro-2-oxo-5-(pyridinyl)-6-(lower-alkyl)nicotinic acids and lower-alkyl esters thereof, and cardiotonic use thereof |
摘要 |
1-R1-6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones or 1-R1-1,2-dihydro-2-oxo-6-(lower-alkyl)-5-(pyridinyl)nicotinic acids or lower-alkyl esters thereof or pharmaceutically-acceptable acid-addition or cationic salts thereof are useful as cardiotonic agents, where R1 is hydrogen, lower-alkyl or lower-hydroxyalkyl. These compounds are prepared by hydrolyzing the corresponding 3-cyano compounds to produce the corresponding 3-carboxylic acids and then either by decarboxylating or esterifying the acids.
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申请公布号 |
US4312875(A) |
申请公布日期 |
1982.01.26 |
申请号 |
US19800204726 |
申请日期 |
1980.11.06 |
申请人 |
STERLING DRUG INC. |
发明人 |
LESHER, GEORGE Y.;OPALKA, JR., CHESTER J.;PAGE, DONALD F. |
分类号 |
A61K31/44;A61K31/4418;A61P9/04;C07D213/50;C07D213/61;C07D213/64;C07D213/73;C07D213/74;C07D213/75;C07D213/77;C07D213/80;C07D213/82;C07D213/85;(IPC1-7):C07D401/04;A61K31/45 |
主分类号 |
A61K31/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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