| 摘要 |
Title compds. I(Ar = 1-naphthyl, 2-naphthyl, inden-4(or 5-)-yl, 3(or 5-)-chloro-2-pyridyl, Ph, substituted Ph; R1 = C1-8 alkyl, Ph, phenylalkyl; R2 = H, lower alkyl; NR1R2 = heterocycle), useful as local anesthetic, antiadrenergic and antiarrhythmic agents were prepd. by reaction of 1-aryloxy-4-chloro-2-butanol(II) and amines(III). Thus, 0.1 mole 1-(1-naphthyloxy)-2-hydroxybutylchloride and 100 ml isopropylamine were heated to 120≦̸C for 24hr, mixed with 6N HCl, and extracted with ether to give 4-isopropylamino-1-(1-naphthyloxy)-2-butanolHCl.
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