发明名称 |
PROCESS FOR PREPARING N-CYANO-N'- 2-/(4-METHYL-5-IMIDAZOLYL) METHYLTHIO/ETHYL N''-ALKENYLGUANIDINES OR THEIR SALTS |
摘要 |
Anti-ulcer agents of the formula <IMAGE> I wherein R1 is a straight or branched chain alkynyl group containing from 3 to 9 carbon atoms, inclusive, are prepared by reacting a compound of the formula <IMAGE> II wherein X is a conventional leaving group, preferably in the form of its acid addition salt, with a compound of the formula <IMAGE> III wherein R1 is as defined above. The intermediates of Formula III may be prepared by reacting a cysteamine salt with an isothiourea of the formula <IMAGE> V wherein R1 is as described above, in the presence of a base. |
申请公布号 |
SU900809(A3) |
申请公布日期 |
1982.01.23 |
申请号 |
SU19782625004 |
申请日期 |
1978.06.02 |
申请人 |
BRISTOL-MEJERZ KOMPANI (FIRMA) |
发明人 |
RONNI REJ KRENSHO,US;DZHORDZH MAJKL LYUK,US |
分类号 |
C07C335/38;A61K31/415;A61P1/00;A61P1/04;C07C67/00;C07C313/00;C07C323/44;C07C325/00;C07D233/54;C07D233/64;C07D277/64 |
主分类号 |
C07C335/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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