| 摘要 |
The present invention provides a process for the preparation of antibacterially active carbapenems of the formula: <CHEM> and salts and esters thereof wherein R<1> and R<2> are independently hydrogen or an organic group bonded via a carbon atom and R<3> is a group NR<4>R<5> wherein R<4> optionally substituted alkyl, aryl and aralkyl, and R<5> is hydrogen or optionally substituted alkyl or R<3> is optionally substituted aryl or alkyl: which process comprises the reaction of a C-3 mercapto carbapenem with an aziridine (CH2)2NCOR<3>.
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