摘要 |
NEW MATERIAL:A tetronolide expressed by formula I (R1 and R2 are H or acyl; R3 is H, acyl or tetronitrose of formula II) and a salt thereof. EXAMPLE:17-O-Tetronitrosyltetronolide expressed by formula III. USE:An antimicrobial agent, an antitumor agent and a synthetic intermediate therefore, administered intravenously or intraperitoneally in a dose of 0.2-0.5mg/kg/day. PROCESS:A microorganism, e.g. Micromonospora chalcea XY11091 strain (FERM-P No.4458, NRRL11289), capable of producing a tetronolide compound expressed by formula IV is cultivated in a untrient culture medium, and the compound expressed by formula IV in the compound expressed by formula I in which R1 and R2 are H respectively is obtained from the culture. The hydroxyl group at the 9 or 21 position of the compound expressed by formula IV is acylated by the chemical synthetic method if necessary to give the remaining compound expressed by formula I. |