发明名称 Immunologically active dipeptidyl 5-0,6-0-acyl-2-amino-2-deoxy-D-glucofuranose derivatives and methods of preparation
摘要 Immunologically active compounds of the formula: <IMAGE> (I.) hydrogen; C1-30 alkyl; C2-30 alkenyl; C1-30 alkoxy; phenyl; C1-20 alkylsulfonyl; or cholesteryl; and R4 may additionally be hydrogen; R5 is hydrogen; or R5-R6 together is -CH2-CH2-CH2; R6 is hydrogen; C1-7 alkyl; hydroxymethyl; mercapto-methyl; benzyl; or substituted benzyl; R7 and R8 may be the same or different and are each independently COOR or CONR'R'', where R is hydrogen or C1-7 alkyl, and R' and R'' are each independently hydrogen or C1-3 alkyl; when R2 is C1-10 alkyl, the stereochemistry at asymmetric center I can be either D or L; when R6 is not hydrogen, the stereochemistry at asymmetric center Ii is L; the stereochemistry at asymmetric center III is D.
申请公布号 US4310514(A) 申请公布日期 1982.01.12
申请号 US19800146806 申请日期 1980.05.05
申请人 MERCK & CO., INC. 发明人 DURETTE, PHILIPPE L.
分类号 A61K39/39;C07J17/00;C07K9/00;(IPC1-7):A61K39/00;A61K37/02;C07C103/52 主分类号 A61K39/39
代理机构 代理人
主权项
地址