发明名称 |
Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species |
摘要 |
Unilamellar vesicles comprising a lipid bilayer, an ionophore being incorporated in said lipid bilayer, a chelating agent entrapped within the vesicles, and an effective amount of physiologically compatible cation bound to said chelating agent within the vesicles. Unilamellar vesicles are loaded by incubating the vesicles with the cation, terminating the incubation and recovering the loaded vesicles by chromatography. In some applications of the invention, the cation may be a radioactive tracer, in which case the vesicles can be administered to the human host and observed by scintillation techniques to produce a radioimage which is useful for diagnostic purposes.
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申请公布号 |
US4310506(A) |
申请公布日期 |
1982.01.12 |
申请号 |
US19800123162 |
申请日期 |
1980.02.20 |
申请人 |
CALIFORNIA INSTITUTE OF TECHNOLOGY |
发明人 |
BALDESCHWIELER, JOHN D.;GAMBLE, RONALD C.;MAUK, MARCIA R. |
分类号 |
A61K9/127;A61K51/12;(IPC1-7):A61K49/00;A61K43/00;B01J13/00 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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