Etherified hydroxy quinazolone compounds

摘要

A compound of the formula (I) in which R1 denotes optionally substituted lower alkyl which is optionally branched at the linking carbon atom, R2 represents hydrogen or lower alkanoyl and R3 is a group of the formula -R3a-(R3b)n- (Ia), in which R3a represents the radical of the formula -N(R4)- or -O- and R4 represents hydrogen or lower alkyl, R3b denotes the radical of the formula -CH2- or, if R3a represents -N(R4)-, denotes the radical of the formula -C(=O)- and n represents nought or 1, and a group of the formula Ia, in which n represents 1, can be linked to the carbonyl group of the carbamoyl grouping either via the group R3a or the group R3b, or acid addition salts thereof, which can be used pharmaceutically can be used as beta-receptor blocking agents for the treatment of disorders in the cardiac rhythm and coronary heart diseases. These compounds also possess a cardio-stimulating action; some of them also display alpha-receptor-blocking properties.