发明名称 |
4,5-Di:hydro-6-acyl:amino-phenyl-3(2h)-pyridazinone derivs. - with thrombocyte aggregation inhibiting and antihypertensive activity |
摘要 |
<p>-pyridazinone derivs. (I) are new. X is O or S; R1 is H or 1-3C alkyl; and R2 is 1-8C alkyl (opt. substd. by 1-4 halogen atoms, 1-4C alkoxy (sepd. from X by at least 2 C-atoms), 3-8C cycloalkyl (opt. carrying 1 or 2 1-3C alkyl gps.) or phenyl (opt. in turn carrying 1-3 substits. from 1-3C alkyl, 1-3C alkoxy, halogen, CF3 or NO2), 3-8C cycloalkyl (opt. mono- to tetra substd. by 1-4C alkyl), 3-8C alkenyl, 3-8C alkynyl or phenyl (opt. carrying 1-3 substits. from 1-4C alkyl, 1-4C alkoxy, halogen, CF3, CN and NO2). (I) have thrombocyte aggregation inhibiting and hypotensive properties. They can be used as antihypertensive agents and for the prophylaxis and treatment of thrombo-embolid diseases. Results of tests for pharmacological activity are given in the spec.</p> |
申请公布号 |
DE3022177(A1) |
申请公布日期 |
1982.01.07 |
申请号 |
DE19803022177 |
申请日期 |
1980.06.13 |
申请人 |
BASF AG |
发明人 |
THYES,MARCO,DR.;FRANKE,ALBRECHT,DR.;KOENIG,HORST,PROF.DR.;LENKE,DIETER,PROF.DR.;DIETER,DR. LEHMANN,HANS;GRIES,JOSEF,DR. |
分类号 |
A61K31/50;A61P7/02;A61P9/12;C07D237/04;(IPC1-7):07D237/04;61K31/50 |
主分类号 |
A61K31/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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