Bicyclo-octatriene derivatives, pharmaceutical compositions containing them and processes and intermediates for their production.

摘要

There are described compounds of formula I <CHEM> in which one of A, B and D represents hydrogen and the other two independently represent -CH2OR or -OR, R represents hydrogen or phenylalkyl, and R<2> and R<3>, which may be the same or different, each represent hydrogen, alkyl or unsubstituted or substituted phenylalkyl, and the pharmaceutically acceptable salts thereof. There are also described processes for producing the compounds by reduction or hydrolysis and pharmaceutical, e.g. cardiac, compositions containing them. compound of formula II, <CHEM> in which one of A<1>, B<1> and D<1> represents hydrogen and the other two independently represent -CHO, -CH2OR<1> or -OR<1>, R<1> represents a blocking group or a group R as defined above, and Q represents -CH2NR<2>R<3>, -CN or -CONR<2>R<3> where R<2> and R<3> are as defined above, provided that R<1> does not represent hydrogen when Q represents -CH2NR<2>R<3>,