PYRANO AND THIOPYRANO (3,4-B) INDOLE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

The invention concerns new compounds of formula I …… in which R<1> is lower alkyl; R<2> is hydrogen or lower alkyl; R<3> and R<4> each independently is hydrogen, lower alkyl, halo, nitro, trifluoromethyl or lower alkoxy; R<5> and R<6> each independently is hydrogen or lower alkyl or R<5> and R<6> together with the nitrogen atom form a pyrrol-1-yl, piperidino or morpholino ring; R<7> is hydrogen or lower alkyl; Alk<1> and Alk<2> each independently is a straight or branched chain lower alkylene having one to six carbon atoms; and X is oxa or thia, and therapeutically acceptable acid addition salts thereof. …The above compounds are diuretic agents, which also possess anti-hypertensive activity. They may be used alone or with other diuretic agents. Pharmaceutical compositions containing the compounds and processes for preparing the compounds are also described.