| 摘要 |
This invention relates to 3-amino-5-substituted-6- halo-N-(3,4-dihydro- or 4,4-disubstituted-6-substituted- 1,3,5-triazin-2-yl)-2-pyrazinecarboxamides. The invention also relates to processes for preparing those compounds of the formula of the tautomeric form thereof <CHEM> wherein R is hydrogen,, C1-5 alkyl, C2-5 alkenyl or C3-6 cycloalkyl; R<1> is hydrogen, C1-5 alkyl, C2-5 alkenyl or C3-6 cycloalkyl; R<2> is hydrogen, or C1-5 alkyl; R<3> is hydrogen, or C1-5 alkyl; R<2> and R<3> can be joined with the carbon atom to which they are attached to form a 3-7 membered carbon ring; X is halo Y is OH, SH, C1-5 alkoxy, C1-5 alkylthio and NR<4>R<5> wherein R<4> is hydrogen or C1-5 alkyl and R<5> is hydrogen, C1-5 alkyl, CN, CONH2, CNH2, NO2 or NH2 NH and the pharmaceutical acid addition salts thereof. The compounds are eukalemic/saluretic agents useful in the treatment of edema and hypertension.
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