DERIVATIVES OF DOXORUBICINE, THEIR PREPARATION AND USE

摘要

New derivatives of doxorubicine of the formula (I) wherein R represents a radical of the formula (II) wherein R1 represents hydrogen, alkyl (possibly substituted with amino, alkylamino, dialkylamino, hydroxy, mercapto or methylthio), phenyl, benzyl (possibly substituted with one or more hydroxy) and R2 represents hydrogen or forms with R1 an alkylene radical, the salts thereof and pharmaceutical compositions containing said compounds. These compounds and their salts possess interesting antitumoral properties together with low toxicity.