发明名称 |
Alkenyl-substituted thienylalkanecarboxylic acids and derivatives thereof |
摘要 |
The invention provides novel omega -(5-alkenylthien-2-yl)alkanecarboxylic acids and their functional derivatives having the formula <IMAGE> (I) wherein n is an integer from 1 to 9, inclusive; R1 is H and R2 is -OH, or R1 and R2 together with the wavy lines represent a keto group; and R3 is H, C1-C6 straight or branched-chain saturated hydrocarbon, or a pharmaceutically acceptable alkali cation. The 3-oxoalkenyl-substituted compounds of formula (I) are prepared by a Wittig-Horner reaction using a 2-oxoheptylphosphonic acid dialkyl ester and an aldehyde of the formula <IMAGE> as starting materials, while the 3-hydroxyalkenyl-substituted compounds are obtained by reduction of the corresponding 3-oxoalkenyl compounds. The esters of formula (I) can also be readily converted to the corresponding acids and salts of formula (I). The compounds of the invention have valuable anti-inflammatory, antipyretic and anti-arteriosclerotic properties, yet have low toxicity and do not irritate the gastric mucosa.
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申请公布号 |
US4309407(A) |
申请公布日期 |
1982.01.05 |
申请号 |
US19800206077 |
申请日期 |
1980.11.12 |
申请人 |
A. NATTERMANN & CIE. GMBH |
发明人 |
LAUTENSCHLAEGER, HANS-HEINER;BETZING, HANS;WINKELMANN, JOHANNES;PROBST, MANFRED |
分类号 |
A61K31/38;A61K31/381;A61P9/10;A61P29/00;C07D333/24;(IPC1-7):A61K31/38 |
主分类号 |
A61K31/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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