5,6-Di:phenyl-3-amino-1,2,4-triazine N-oxide derivs. - useful as analgesics and thrombocyte aggregation inhibitors

摘要

Triazine N-oxide derivs. of formula (I) and their pharmaceutically acceptable acid addn. salts are new. (The N-oxide is at the 1 or 2 position. X and Y are H, halo, alkoxy or hydroxy. R1 and R2 are H, alkyl (opt. substd. by hydroxy, halo or dialkylamino), aralkyl (opt. substd. by one or more methoxy), pyrrolidinoalkyl, morpholinoalkyl, alkenyl, benzoyl or alkoxycarbonylalkyl, or together they complete a 5 or 6 membered heterocycle such as morpholino or piperazino (opt. 4-substd. by alkyl, hydroxyalkyl or aralkyl)). They are made by reacting a 3-aryloxy analogue with HNR1R2. (I) are useful in human or veterinary medicine as analgesics and thrombocyte-aggregation inhibitors, partic. useful for treating migraines. In mice, the oral LD50 is over 1.5 g per kg and the ED50 against benzoquinone-induced writhing is 2-10 mg per kg.