Material able to fix reversibly biologial macromolecules, its preparation and its application

摘要

A process for preparing a porous solid material for use in a chromatography column and which is capable of fixing reversibly biological macromolecules comprises coating a porous inorganic support with a polysaccharide polymer having alpha -glycol groups which undergo oxidative scission, subjecting the polysaccharide polymer to an oxidative scission reaction, reacting the resulting oxidized polysaccharide polymer with an amino molecule or macromolecule having the formula R'-NH2 to produce a polysacchride polymer having the formula R4-CH=N-R' and reducing the imine bond in said immediately above defined polysaccharide polymer to a stable amine bond.