| 摘要 |
1-Fluoromethyl-substituted alkyl-amines of formula: R - CH(CH2F) - NH2 are disclosed. R can be 3,4-diR10- benzyle, (R1 is hydrogen or C2-C6 alkanoyl), hydroxybenzyl, benzyl, 4-methylene-imidazole, 3-methylene- 5-hydroxy-indole, 3-methylene- indole, 2-carboxyethyl, 3-carboxy-3- aminopropyl, and 4 carboxy-4 amino-butyl. These compounds can be prepared by fluorinating the corresponding 1-hydroxymethyl- substituted alkylamines, or the corresponding 1-methyl- alkylamines. They have decarboxylase inhibiting activity. |
