| 摘要 |
<p>The present invention relates to a method of peptide production by protein engineering. This method involves the culturing of genetically engineered bacteria which produce as extracellular structures type (4) fimbriae, the peptide being produced in association with these fimbriae. This method is applicable to the production of virtually any peptide or peptides. The engineered bacteria contains the gene encoding the fimbrial subunit of type (4) fimbriae to which has been added at the C-terminal end the nucleic acid sequence encoding the peptide of choice, together with a system for morphogenetic assembly of type (4) fimbriae such that fimbriae in association with the peptide are produced as extracellular structures.</p> |
