DIOXACYCLOALKANE COMPOUND WITH RENIN-INHIBITING ACTIVITY

摘要

A dioxacycloalkane compound represented by general formula [1], a pharmaceutically acceptable salt thereof, an intermediate for producing the compound, and a process for producing the intermediate. The compound [1] has a potent activity of inhibiting renin and a persistent hypotensive effect by peroral administration, thus being useful as a hypotensive and a remedy for cardiac insufficiency. General formula [1] wherein A represents [a] or [b]; W represents [c], [d] or [e], X represents -CO- or -SO2-; Y represents -CH2, -O- or -NR<25>-; R<1> represents aralkyl which may be substituted by lower alkoxy; R<2> represents hydrogen or lower alkyl; R<3> represents -(CH2)d-SR<26> or [f]; R<4> and R<5> represent each hydrogen or lower alkyl; and E represents -C(R<29>)(R<30>)- or -CH2CH2-.