| 摘要 |
<p>1,1 min -biphenyl-2-yl alkylamine derivatives of formula (I): <CHEM> wherein: X is hydrogen or a halo substituent at any position in the phenyl ring; R<1> is hydrogen, hydroxy, C IDENTICAL N, CONR<5>R<6>, or CO2R<8> where R<5>, R<6>, R<8> independently represent hydrogen or alkyl; R<2> is hydrogen or alkyl; Z is -(CH2)n- or -CH2@@CH2-; where n is an integer of from 2 to 4; R<3> and R<4> independently are hydrogen, C1-6 alkyl, CH2C2-5 alkenyl, phenyl C1-3 alkyl, or taken together with the adjacent nitrogen atom form a heterocyclic group or a pharmaceutically-acceptable salt thereof. The compounds are prepared by the usual methods for analogous compounds. They have been found to be effective in the treatment of cardiac arrhythmias. Pharmaceutical formulations have been prepared.</p> |
