发明名称 |
3-Aminosydnonimines, their preparation and use |
摘要 |
Physiologically-acceptable 3-aminosydnonimines of the formula <IMAGE> (I) and their pharmacologically-acceptable acid-addition salts, when formulated into medicament dosage forms, are useful for reducing systemic blood pressure, pulmonary artery pressure and left ventricular end diastolic pressure when orally administered to patients in need of such pressure reduction. These compounds are prepared by cyclizing a compound which, in its free-base state, is of the formula <IMAGE> (II) to a corresponding product which, in its free-base state, is of the formula <IMAGE> (Ia) and, when R2 is other than -H, acylating that product.
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申请公布号 |
US4305939(A) |
申请公布日期 |
1981.12.15 |
申请号 |
US19800166951 |
申请日期 |
1980.07.08 |
申请人 |
CASSELLA AG |
发明人 |
SCHOENAFINGER, KARL;BEYERLE, RUDI;NITZ, ROLF-EBERHARD;MARTORANA, PIERO A.;FIEDLER, VOLKER |
分类号 |
C07D413/04;A61K31/4245;A61K31/425;A61K31/495;A61K31/496;A61K31/54;A61P9/00;A61P9/12;C07D271/04;C07D295/28;C07D413/06;C07D417/04;(IPC1-7):C07D271/04;C07D279/10;A61K31/38;A61K31/41 |
主分类号 |
C07D413/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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