| 摘要 |
<p>The invention concerns the manufacture of new 1,3,4,14b-tetrahydro-2H,1OH-pyrazino1,2-alpyrrolo2,1-c 1,4lbenzodlazeplnes of the formula (I) wherein each of R1, R3 and R4 is hydrogen or lower alkyl; R2 is hydrogen, lower or higher alkyl, lower alkenyl, lower alkynyl, or (3 to 7 ring-membered cycloalkyl, hydroxy, carboxy, lower carbalkoxy, carbamoyl, HPh, lower alkanoyl or HPhCO)-lower alkyl; Ph is 1,2-phenylene, unsubstituted or substituted by up to two members selected from lower alkyl, lower alkoxy, halogeno and trifluormethyl; CnH2n is lower alkylene separating both nitrogen atoms by 2 or 3 carbon atoms and R5 is hydrogen, lower alkyl, lower carbalkoxy or hydroxy-lower alkyl; the lower alkoxycarbonyl, lower or higher alkanoyl, adamantoyl, carbamoyl, or HPhCOderivatives; the 2-N oxide, 2-lower alkyl or 2-HPh-lower alkyl quaternaries of a compound in which R2 is different from hydrogen; and acid addition salts thereof, which exhibit antidepressant, analgesic and antihistaminic properties.</p> |
