发明名称 |
IMMUNOASSAYS FOR DETERMINATION OF LSD AND LSD METABOLITES |
摘要 |
To improve the detection of LSD in biological samples, antibodies are raised to LSD conjugated to a protein carrier, preferably through the indole ring. Selected antibodies are matched with an immunoassay reagent in which the LSD is conjugated in the same position to a labeling or separation means. The set of reagents can be used in immunoassays with remarkably little cross-reactivity with potential interfering substances such as chlorpromazine and ergotamine, and a low false-positive rate in a panel of clinical test samples. Also provided is a set of reagents for measuring glucuronide metabolites of LSD by immunoassay, which permits exposure to LSD to be determined over a longer diagnostic window.
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申请公布号 |
WO9942840(A1) |
申请公布日期 |
1999.08.26 |
申请号 |
WO1999US03662 |
申请日期 |
1999.02.19 |
申请人 |
MICROGENICS CORPORATION |
发明人 |
SIGLER, GERALD, F.;ROUHANI, RIAZ;DAVOUDZADEH, DAVID;COTY, WILLIAM, A.;SHINDELMAN, JEFFREY, E.;MORRILL, PAUL, R. |
分类号 |
C07D457/06;G01N33/94;(IPC1-7):G01N33/94;C07K16/16;C07K16/44 |
主分类号 |
C07D457/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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