| 摘要 |
<p>NEW MATERIAL:A quinone compound expressed by formula I (R<1> is methyl or methoxy, or two R<1> is formed formula II; X is formula III or IV; Y<1> is H, OH, carboxyl, amide, N-substituted amide, cyano, etc.; m is an integer 0-3; n is an integer 0-10; n' is an integer 1-5; k is an integer 1-3; and when k is 2 or 3, n' may be optionally changeable in the range of 1-5 on repetition two or three times or its hydroquinone derivative. EXAMPLE:2,3-Dimethoxy-5-methyl-6-(9-hydroxynon-5-ynyl)-1,4-benzoquinone. USE:A medicine or its intermediate useful as an antiasthmatic agent, antiallergic, hypotensive, antiulcer, diuretic or antithrombotic agent with low toxicity. PROCESS:A compound expressed by formula V (R<2> is H, OCH3, etc.; R<3> is CH3, methoxymethyl, etc.; Y<2> is Y<1>, etc.) is subjected to the eliminting reaction of the protecting groups and oxidized, if necessary, to give the quinone expressed by by formula I or its hydroquinone derivative.</p> |
