Solid support matrices containing a toxin binding oligosaccharide

摘要

Disclosed are solid support matrices having a toxin-binding oligosaccharide covalently attached to a solid support through a linking arm which has at least 8 atoms separating the oligosaccharide from the solid support. These solid support matrices are useful for neutralizing toxins from disease-causing microorganisms. The support matrices are of the formula shown where SS is a solid support; W is S or O; X and Y are each NH, O or S; Z is a toxin-binding oligosaccharide, p is an integer of 0-50; n is the loading level integer of the support; R3 is H of C(O)R, R2 is a hydrocarbene group and R1 is a covalent bond or a hydrocarbene group.