ANTIBACTERIAL MONIC ACID C DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM

摘要

Monic acid C and its salts and esters of formula (II):

where R is a salt-forming ion or pharmaceutically acceptably ester-forming radical may be prepared by either converting the epoxide in the known monic acid A to an olefin, or by hydrolysis of the naturally occurring pseudomonic acid C. The esters of monic acid C have antibacterial and antimycoplasma activity and are therefore useful in the treatment of human and veterinary bacterial and mycoplasma-induced infections.