发明名称 |
ARTIFICIAL ERYTHROCYTE AND MANUFACTURE THEREOF |
摘要 |
A process for preparing artificial red cells comprising microdroplets of aqueous, stroma-free hemoglobin solution encapsulated in membranes of polymerized hemoglobin, said process comprising forming microdroplets of hemoglobin solution in a continuous oil phase, cross-linking the hemoglobin at the surface of the microdroplets with a suitable cross-linking agent to form the artificial red cells and recovering the cells. In one embodiment, a liquid membrane encapsulation technique employing a water-soluble cross-linking agent is used to form the cells. In another embodiment an oil-soluble cross-linking agent is present in the oil phase containing the hemoglobin microdroplets. |
申请公布号 |
JPS56152424(A) |
申请公布日期 |
1981.11.26 |
申请号 |
JP19810054231 |
申请日期 |
1981.04.10 |
申请人 |
EXXON RESEARCH ENGINEERING CO |
发明人 |
TOOMASU EI DEIBUISU;UIRIAMU JIEI AASHIYAA |
分类号 |
A61K38/16;A61K9/107;A61K9/50;A61K35/18;A61K38/00;A61P7/08;C07K14/805 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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