| 摘要 |
<p>This invention discloses a new and commercially useful process for the preparation of phonoxypropylamine derivatives of the general formula (I): (I) and the acid addition salts thereof wherein R is a hydrogen atom or an alkyl group, R1 is an alkyl, cycloalkyl, aralkyl or aryl group, or R and R1 together represent a divalent optionally branched hydrocarbon, optionally substituted, R2 is a hydrogen atom or an alkyl, aralkyl or aryl group, R3 is an alkyl, hydroxyalkyl, cycloalkyl or cyanoalkyl group and x is an oxygen atom or the group -NOR4, wherein in the case where X is oxygen R2 is not hydrogen and R4 is a hydrogen atom, a lower alkyl group or an aralkyl group. This process comprises reacting a urea derivative of the general formula (II): with an amine of the general formula (III): at elevated temperatures and then the product of formula (I) is isolated as the free base or acid addition salt thereof.</p> |
