摘要 |
Title compds. (I; R = halogen, nitro, lower alkyl, lower akloxy, hydroxy or H; R1 = H, lower alkyl, lower alkenyl, or -CH2(CH2)pR2; R2 = aromatic alkyl, cyclic lower alkyl; p = 0-3; n = 1-5) were prepd. by cyclization of XIII. Thus, 253.9 g (-)-1-(P-methoxybenzyl)-2-methyl-1,2,3,4,5,6,7,8-octahydroisoquinoline and 260 g potassium hydroxide were reacted at 210≦̸C in N2 gas for 36 hr to give (-)-1-(P-hydroxybenzyl-2-methyl-1,2,3,4,5,6,7,8-ocatahydroisoquinoline.
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