发明名称 Sulfonamide intermediates for adrenergic blocking agents
摘要 There are disclosed compounds of the formula <IMAGE> wherein R1 is selected from the group consisting of lower alkyl; R8 is selected from the group consisting of -O-(CH2)n- wherein n is 2 to 20, <IMAGE> and R6 is selected from the group consisting of hydrogen or lower alkoxy, and <IMAGE> wherein R1 is selected from the group consisting of lower alkyl; R8 is selected from the group consisting of -O-(CH2)n- wherein n is 2 to 20, <IMAGE> and R6 is selected from the group consisting of hydrogen or lower alkoxy and racemates thereof. There are also disclosed processes and intermediates utilized to produce the end products. The end products have utility as agents exhibiting both alpha and selective beta adrenergic blocking action.
申请公布号 US4301300(A) 申请公布日期 1981.11.17
申请号 US19800180258 申请日期 1980.08.22
申请人 HOFFMANN-LA ROCHE INC. 发明人 FAHRENHOLTZ, KENNETH E.;GUTHRIE, ROBERT W.;KIERSTEAD, RICHARD W.;TILLEY, JEFFERSON W.
分类号 A61K31/495;C07D295/00;C07D295/067;C07D295/092;C07D295/15;C07D303/22;C07D317/20;C07D317/22;C07D317/24;C07D317/26;C07D317/28;C07D317/30;C07D317/34;(IPC1-7):C07C143/75;C07C143/79 主分类号 A61K31/495
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