| 发明名称 |
Method of producing hepatitis B surface antigen |
| 摘要 |
Hepatitis B surface antigen (HBsAg) is produced in vitro in high titer and purity from tissue cultures of cells that shed HBsAg by growing the cells with a first incubation at elevated temperature followed by a second incubation at a lower elevated temperature.
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| 申请公布号 |
US4301250(A) |
申请公布日期 |
1981.11.17 |
| 申请号 |
US19790090169 |
申请日期 |
1979.11.02 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
MCALEER, WILLIAM J.;MARKUS, HENRY Z. |
| 分类号 |
C12N7/00;A61K39/29;C07K14/02;C12N5/02;(IPC1-7):C12N5/02;C12P21/00;C12M3/04 |
主分类号 |
C12N7/00 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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