PROCESS FOR CONCENTRATING BLOOD COAGULATION FACTOR XIII DERIVED FROM HUMAN PLACENTAE

摘要

The invention relates to a process for concentrating blood coagulation Factor XIII (Fiblin stabilizing factor) which comprises removing a fraction precipitated at a pH of 6 to 9 in a concentration of 4 to 9 % (W/V) of an alkylenoxide polymer or copolymer having a molecular weight of 2,000 to 20,000 from a crude globulin fraction obtained from human placentae by separating an albumin fraction therefrom, and then collecting the fraction precipitated in the concentration of 20 to 30 % (W/V) of said polymer or copolymer, thereby obtaining easily said blood coagulation Factor XIII free from pyrogen in good yield.