| 摘要 |
Bicyclic 1-oxa- beta -lactam diacid antibiotics represented by the formula <IMAGE> wherein R is phenyl, hydroxyphenyl, acetoxyphenyl, alkylphenyl, or halophenyl, thienyl or furyl; R DEG is H or OCH3; and the pharmaceutically acceptable non-toxic salts thereof are broad spectrum antibiotics useful for controlling infections in man and animals. The compounds are prepared by reacting the corresponding 3-halomethyl diester with 1-cyanomethyl-1H-tetrazole -5-thiol followed by deesterification.
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