NMR BIOMARKERS TO PREDICT THERAPY RESPONSIVENESS

摘要

The invention relates to the treatment of osteoporosis. More specifically, it relates to biomarkers that allow to predict the response to therapy in an osteoporotic subject. Provided is a difference profile for predicting the response to calcium / vitamin D therapy of an osteoporotic subject, preferably a human subject, comprising a plurality of NMR spectral line positions and, optionally, corresponding signal intensities of NMR spectral lines, which express the normalized difference between one or more NMR spectra of metabolites in a body fluid of one or more osteoporotic subjects known to be responsive to calcium / vitamin D therapy, and one or more corresponding NMR spectra of metabolites in a corresponding body fluid of one or more osteoporotic subjects known to be unresponsive to said therapy and wherein NMR spectra are recorded prior to said therapy. Also provided is a method for predicting the responsiveness to vitamin D/ calcium therapy in an osteoporotic subject making use of a difference profile of the invention.