| 摘要 |
Hypoglycemic guanylamidines of the formula …<CHEM>… or pharmaceutically acceptable acid addition salts thereof,… wherein R1 and R4 are each selected from phenyl; phenyl monosubstituted with chloro,bromo, fluoro, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 3 carbon atoms; benzyl; naphthyl, pyridyl, quinolyl, fury, thienyl and pyrimidinyl;… and Y is …<CHEM>… or -NR2R3,… wherein… n and m are each 1, 2 or 3, with the proviso that the sum of n and m is 3, 4 or 5;… Z is CH2, O, S, SO, SO2, NH or NCH3;… and R2 and R3 are each selected from n-alkyl of 1 to 4 carbon atoms; alkoxyethyl wherein said alkoxy group is of 1 to 3 carbon atoms; phenyl; and phenyl monosubstituted with chloro, bromo, fluoro, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 3 carbon atoms; processes for their production, and pharmaceutical compositions containing them. |
