Inhibitors of dipeptidyl peptidase IV

摘要

Compounds according to general formula (1), wherein R¹ is H or CN, X¹ is S, O, SO₂ or CH₂, X² is O, S or CH₂, X³ is NR⁵ or a carbonyl or thiocarbonyl group and R⁴ is R⁶R⁷N, R⁸(CH₂)_qOC(-O), R⁸(CH₂)_qOC(-S), R⁶R⁷NC(-O), R⁶R⁷NC(-S); R⁸(CH₂)_qC(-O), R⁸(CH₂)_qC(-S) or R⁸(CH₂)_qSO₂, m is 1-3 and n is 0-4 are new. The compounds of the invention are inhibitors of dipeptidyl peptidase IV. Pharmaceutical compositions of the compounds of the invention, or pharmaceutically acceptable salts thereof, are useful in the treatment of, inter alia, type 2 diabetes