摘要 |
There is disclosed the preparation of compounds of the formula FORMULA 1 wherein Het is a 2- or 4-imidazolyl ring optionally substituted by lower alkyl (preferably methyl), halogen(preferably chlorine or bromine), trifluoromethyl or hydroxymethyl, a 2-pyridyl ring optionally substituted by lower alkyl (preferably methyl), lower alkoxy (preferably. methoxy), halogen (preferably chlorine or bromine), amino or hydroxy, a 2-thiazolyl ring, a 3-isothiazolyl ring optionally substituted by chlorine or bromine, a 3-(1,2,5)-thiadiazolyl ring optionally substituted by chlorine or bromine, or a 2-(5-amino-1,3,4-thiadiazolyl) ring; Y is sulphur or a methylene group; Z is hydrogen or lower alkyl(preferably methyl); X is oxygen or sulphur; W is methylene, oxygen or sulphur: p and q are such that their sum is from 1 to 4 when W is oxygen or sulphur, or from 0 to 4 when W is methylene; Het' is a 5 or 6 membered heterocycle such as pyridine, furan,thiophen, thiazole, oxazole, isothiazole, imidazole, pyrimidine, pyrazine or pyridazine,which ring is optionally substituted by lower alkyl, lower alkoxy, or may have a benzene ring or substituted benzene ring fused to it. The compounds have been found to be histamine H2- antagonists and are useful as inhibitors of gastric acid secrection, as antiinflammatory agents and as agents which act on the cardiovascular system. |