| 摘要 |
PURPOSE:To obtain the titled extract useful for the treatment of the cardiac insufficiency, etc. with very high safety, by extracting Annona muricata L. or its allied plant of the same genus. CONSTITUTION:Annona muricata L. [Japanese name: togebanreishi (family Annonaceae)] is a plant native to the Continent of South America. The leaf thereof is used as a tea, and the fruit is used for food. The Annona muricata L. or its allied plant of the same genus, particularly the leaf thereof, is extracted with water, a polar organic solvent or a mixed solvent thereof, and the resultant extract is concentrated or dried, and preferably purified by the column chromatography or gel filtration method to give a crude extract containing a cardiac active substance exhibiting a powerful cardiac activity by the intravenous and systemic administration, e.g. intraduodenal administration, with high safety and relatively weak influence on the blood pressure and heart rate particularly due to the food component, and effective even by the oral administration. |
