METHOD OF PREPARING CORTICOIDS

摘要

Corticoids of the formula <IMAGE> wherein represents a single bond or a double bond; X is hydrogen, fluorine, chlorine or methyl; Y is hydrogen and Z is hydrogen, fluorine or chlorine, or Y and Z together are a carbon-to-carbon bond; V is beta -hydroxymethylene, beta -chloromethylene or carbonyl; W is methylene, ethylidene or vinylidene; Q is oxygen or sulfur; R1 is alkyl of 1-8 carbon atoms, alkyl of 2-8 carbon atoms with an oxygen atom between two of the carbon atoms or benzyl, and R2 is hydrogen or alkyl of 1-4 carbon atoms, or R1 and R2 collectively are trimethylene or tetramethylene; and R3 is hydrogen, fluorine, chlorine, hydroxy, or hydroxy esterified by a C1-16 hydrocarbon carboxylic acid have valuable pharmacological properties, e.g., anti-inflammatory activity.