| 摘要 |
NEW MATERIAL:An N<4>-carbamoylpiperazinopropanol derivative expressed by formula I [R is formula II [R1 is <=6C alkyl and cycloalkyl, etc. which may have an unsaturated bond; R2 is H or CH3; Z is -CH2CH2NHCO2R3 (R3 is <=4C lower alkyl), -NHSO2R3, etc.], formula III (n is 1-2), formula IV, etc.] and an acid addition salt thereof. USE:A beta-blocking agent, capable of inhibiting the nervous transmission by the antagonism of the sympathetic peripheral beta-acceptor, and usable for various circulatory diseases, e.g. hypertension, angina pectoris or arrhythmia, and diseases, e.g. lipid metaboilc disorder, with low toxicity. PROCESS:An aryl glycidyl ether, e.g. 3-(6-bromothiochroman-4-ylideneoxido)-1,2- epoxypropane, is reacted with N-carbamoylpiperazine in an unreactive solvent, e.g. an alcohol, to give the compound of formula I. |
